Principles of Psychobiology© Module Overview

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Principles of Psychobiology is a self- contained software package that can be used with or without an introductory textbook in the brain sciences.

· Contents ·

1. Resting Membrane Potential

·Review of Cell Biology - Contents: Organelles, CNS glia and common synaptology, DNA transcription. RNA translation.
· Review of Electrical Theory - Passive Membrane Properties; Contents:Current; Background, Equipment; Membrane Model, Example. Voltage; Background, Neural Circuits, Membrane Models, Membrane Voltage. RC Effects; Background, Equipment, Membrane Model, Time Constants.
· Resting Membrane Potential - Contents: Chemical and Electrostatic forces; Channel Tutor, Ion Concentrations, Nernst Potential, Goldman Equation, Ion Animation (equilibrium), Ion Cloud Model. Student access to manual, Active Glossary, Psychobiology Help, and Student Notebook. Resting Memebrane Module

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2. Action Potential

· Action Potential - Contents: Goldman Equation, Ion Concentrations, Ion Flow Animation, Channel Timing and effects of toxins/poisons of activation/inactivation gates. Refractory States. Student access to manual, Active Glossary, Psychobiology Help, and Student Notebook. Action Potential Module

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3. Membrane Conduction

· Membrane Conduction - Contents: Decremental Conduction, Membrane Model, Length Constant, Synaptology, "Make it Work", Altered States, Regenerative Conduction, Influence of Myelin. Stimulation experiments with decremental and regenerative (saltatory) conduction; manipulation of conduction by changes in passive elements (Rm / Rl). Student access to manual, Active Glossary, Psychobiology Help, and Student Notebook. Conduction Module

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4. Post-Synaptic Potentials

· Post-Synaptic Potentials - Contents: Goldman Equation, Neurotransmission including Degradative Enzymes, Re-uptake Mechanisms, Storage/Release, Receptor Poisons/Toxins, Animation of Chemical Neurotransmission, Thresholds for Action Potentials, Temporal Summation Experiments, Gap Junctions. Student access to manual, Active Glossary, Psychobiology Help, and Student Notebook. Post Synaptic Potential Module

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5. Introduction to Human Neuroanatomy

· Explore the Brain - Opening Screen Contents: Telencephalon; Neocortex, Basal Ganglia, Amygdala, Hippocampus. Diencephalon, Midbrain, Hindbrain, Spinal Cord. The Basic Plan of the Chordate Brain, Vascular System; Arterial Plan, Review Planes and Directions.
· Neocortex - Topics: Architecture; Association/Commissural Pathways, Brodmann's Scheme, Cortical Cell Morphology and Columns, Corticospinal and Corticobulbar Motor Systems, Alzheimer's Disease.
· Amygdala - Topics: Organization, Connectivity and Functions.
· Basal Ganglia - Topics: Organization, Connectivity and Functions; Altered States: Parkinson's Disease.
· Hippocampus - Topics: Organization, Connectivity and Functions. Perforant Pathway Animation.

Anatomy Start-Up Screen

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· Thalamus and Hypothalamus - Topics: Organization, Connectivity and Functions. Specific and Non-specific Thalamic Nuclei and Neocortical Targets.
· Midbrain - Topics: Organization, Connectivity and Functions. Rubrospinal System, Altered States - Parkinson's Disease: Clinical Attempts at Treatment; Enrichment, Transplants, Stimulation.
· Medulla - Topics: Organization, Connectivity and Functions. Cerebellum; Major Circuits, Cranial Nerves.
· Spinal Cord - Topics: Organization, Connectivity and Functions. Autonomic Nervous System.
All anatomy modules utilize detailed human coronal sections (8 separate modules called from the opening screen above). Segregation of information presentation into sensory, motor, and integrative schemes. Extensive student practicums with Macroscope Viewer and Lab Draw.

6. Neurochemical Anatomy

· Neurochemical Anatomy - Topics: Major organizational schemes of classical transmitters. Criteria for establishing classical transmitters, synthesis/degradation, illustration of synthesis / degradation. Description and illustration of experiments involving immunological, autoradiographic, and lesion manipulations. Detailed coverage of anatomy and synaptology of classical transmitter systems summarized from Handbook of Neurochemical Anatomy. Neurochemistry Start-up Screen

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7. Sensory Transduction and Receptor Systems

· Sensory Transduction and Receptor Systems - Topics: Receptor transduction including adequate stimuli, range fractionation, thresholds, theories of coding, and power law relationships. 5 separate modules on vision, audition, somatosensation, gustation, and olfaction. Major themes of transduction mechanisms at the membrane, receptive fields, "best responses", intensity coding, quality coding, CNS connections, and clinical observations following damage. Sensory Start-up Screen

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Student Resources

Student resources include Psychobiology Help with Active Glossary, Notebook including module reviews and practice exams, Exam editor (formal exam archive must be decompressed using password provided by faculty member), Macroscope Viewer with high resolution (120 screen dpi) color coronal sections of the forebrain, midbrain, hindbrain and spinal cord, Lab Draw with "coloring book" feature, Student Resource Quick Start screen, answer keys to Notebook practice exams. (see below for details on these resources) Student Resources